Atlas Of Hematology by Nivaldo Medeiros, MD

This Atlas has the goal of supplying hematologists, laboratory technicians, medical school students, biologists as well as professionals working in the field of morphology of blood cells.

The majority of the smears come from blood and bone marrow samples, however note that also are shown here cavitary fluid materials, scraped, etc.

The panchromic stain used is always "Leishman", and are added in addition rare cytochemistry reactions.

The pictures taken were scaled up of magnifications such: x200;x400; x630; and specially x1,000 with photomicroscopes Zeiss and Nikon.

These pictures show normal cells from blood and bone marrow and continuing to a substantial variety of hematologic diseases, being some of these rather
Fotografias de Maduracion en Medula Osea, alteraciones eritrocitarias, Anemias, Leucemias, etc. Para acceder haga Click Aqui.

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Immunoglobulin M (IgM) multiple myeloma versus Waldenström macroglobulinemia: diagnostic challenges and therapeutic options: two case reports

Autors: Simona Elba , Alessia Castellino , […] Massimo Massaia volume details Abstract Background Immunoglobulin M multiple myeloma and Waldenström macroglobulinemia are two different hematological diseases with the common finding of an immunoglobulin M monoclonal gammopathy of unknown significance. However, clinical characteristics of the two entities can overlap. Case presentation In this report, we describe two cases of immunoglobulin M neoplasm with the same histological bone marrow presentation but with different clinical behavior, cytogenetics, and biological assessment. On the basis of comprehensive diagnostic workup, these patients were considered to have different diseases and treated accordingly with different approaches. Patient 1 (Caucasian man) presented with increased serum protein and immunoglobulin M (7665 mg/L) with an M-spike electrophoresis of 4600 mg/L. His bone marrow biopsy revealed a small-cell immunoglobulin M mul...

E-Learning Library By Clinical Cytometry Education Network (CCEN)

E-Learning Library Internet-based technology is capable of addressing many of the challenges faced in providing global flow cytometry education. According, we strive to expand the availabilty of web-based educational materials and to build a comprehensive electronic library including: Online Courses A collection of formal presentations from invited experts covering a broad range of clinical cytometry topics. Slide-based presentations will be supplemented with notes, audio, video, or real-time interaction (webinar). Short Instructional Videos Short, 5 – 15 minute, videos addressing practical aspects of clinical flow cytometry, including identification of individual cells, an approach to the diagnosis of specific disease entities, how to avoid pitfalls, and technical tips. Clinical Case Studies A comprehensive portfolio of clinical case studies with provision of relevant clinical information, the results of other laboratory testing, and raw cytometry data thro...

How can aberrant B lymphoblasts in B lymphoblastic leukemia (B-ALL) be distinguished from hematogones?

Hematogones are immature B-cell precursors that are found primarily in the bone marrow from which they arise. They are found in greatest abundance in infants and young children and decline with age. They are frequently increased in regenerating bone marrow after chemotherapy or bone marrow transplant, but also can be increased in other inflammatory, hematologic, oncologic, and inflammatory disorders. They are rarely detected in peripheral blood. It is particularly important to be able to differentiate hematogones from neoplastic B-cell precursors in the diagnosis and monitoring of B-ALL. B-lineage lymphoblasts and hematogones often share immunophenotypic characteristics. Thus, hematogone hyperplasia can be mistaken for B-ALL at diagnosis and regenerating hematogones can be mistaken for minimal residual disease after therapy. Figure 1A shows normal B-lineage maturation. All hematogones are positive for CD19 (not shown) and show variable expression of CD58. The earliest hematogones...

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